Cancer can be a very traumatic experience for the people affected and the majority of the literature focuses on this. Unbeknown to many, it is increasingly recognised that as a result of struggling with such traumatic adversities, some people show what is known as post-traumatic growth (PTG). It not only allows people to overcome their trauma (e.g. impact of cancer) and return to pre-diagnosis functioning (e.g. health, wellbeing, employment), but even results in them going over and above their previous state (e.g. increased resilience). This renders PTG an important phenomenon that should be part of the support people with cancer receive. This project has two parallel paths. On one, is the development of health policy and best practice recommendations about the psychosocial support of people with cancer in Greece. On the other, is a sequence of three studies, starting with a systematic review, which is followed by a cross-sectional study and concludes with a randomized control trial (RCT). The systematic review and close collaboration with experts (e.g. patient societies) will lead to the development of a novel manual to facilitate PTG in groups of people with cancer. The cross-sectional will then explore relationships between variables (e.g. PTG, quality of life, biomarkers, illness perceptions, distress, anxiety, depression) in people with cancer (n = 180-210). Lastly, the RCT will evaluate the intervention’s effects on the same variables and people compared to the different groups (breast, bowel and head and neck cancers, n = 60-70 per group).