CERTH will coordinate together with other partners (Univ Paris-D, Univ Paris-MC) a WorkPackage on Bioinformatic approaches for antigen receptor gene repertoire analysis in lymphoid malignancies. For this purpose an immunoinformatics pipeline for NGS-based IG/TR gene repertoire (meta) analysis needs to be created to address generic challenges. Additionally, statistics and algorithms for IG somatic hypermutation analysis and interpretation in lymphoid malignancies need to be developed. This platform shall also impact on the broader EuroClonality-NGS activities.”
