The “PureCell – Towards Precision Medicine: Advanced cellular analytics in biomedical research” proposal was built with the main aim to leverage the institutional capacities of the Institute of Applied Biosciences at the Centre for Research and Technology Hellas (INAB-CERTH) in biomedical research, with a particular focus on research initiatives related to precision medicine. Capitalizing on the presence of a high-skilled workforce, state-of-the-art infrastructure for omics studies (including in vitro and in silico analysis), scientific and technological excellence and extensive experience of joint initiatives in Greece and abroad, within only 4 years in existence, INAB-CERTH has accomplished landmark achievements in biomedicine, especially in cancer with a main emphasis on dissecting cancer pathophysiology towards enhancing the fundamental understanding of cancer and improving patient care. Through this present proposal, INAB-CERTH aims to expand its current activities by incorporating new technologies and relevant instrumentation, including (i) Cell Sorter + associated Flow Cytometry; and, (ii) Metabolic Kinetics infrastructure. The expanded capacity will integrate with our existing –omics facilities and amplify its impact in Precision Medicine. We aim towards the establishment of a National Open Infrastructure for Advanced Cellular Analytics in biomedical research that will be relevant to not only INAB-CERTH scientists and collaborators but the academic sector at large that will have increased opportunities for cutting-edge research.