{"id":2324,"date":"2024-12-22T21:54:06","date_gmt":"2024-12-22T21:54:06","guid":{"rendered":"https:\/\/www.inab.certh.gr\/project\/neocll\/"},"modified":"2024-12-22T21:54:06","modified_gmt":"2024-12-22T21:54:06","slug":"neocll","status":"publish","type":"project","link":"https:\/\/www.inab.certh.gr\/el\/project\/neocll\/","title":{"rendered":"NeoCLL"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Recent next-generation sequencing (NGS) studies by our group documented the clonal architecture of the T cell repertoire in CLL, with T cell clones which persist and expand over time in treatment-naive CLL, appear disease-specific and may be shared among different patients, especially those belonging to stereotyped subsets, thereby indicating selection by restricted antigens that could actually be acting in a CLL subset-specific context. Furthermore, we have shown that BcR signaling inhibitors retain T cell clones that may have developed in response to tumor antigens; importantly, at least in the case of rituximab-idelalisib, these clones expand and may become activated, possibly contributing in the clinical response. Based on our extensive, albeit indirect, immunogenetic evidence regarding the existence of tumor-specific T cell clones that can potentially be recruited into antitumor responses, we here propose how to formally identify and fully characterize both immunogenic neoepitopes and the CD8 T cells that recognize them. We will take advantage of a novel, high-throughput method for detecting antigen-specific T cells using DNA-barcoded peptide-MHC-I multimers. Our study will focus on neoepitopes that may be conserved amongst CLL patients, with the ultimate goal to explore the possibility for a stratified treatment by means of engineered T cells or by peptide vaccines targeting such conserved epitopes.&#8221;<\/span><\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"class_list":["post-2324","project","type-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project\/2324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/types\/project"}],"wp:attachment":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/media?parent=2324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}