{"id":2318,"date":"2024-12-22T21:49:41","date_gmt":"2024-12-22T21:49:41","guid":{"rendered":"https:\/\/www.inab.certh.gr\/project\/cll-ibru\/"},"modified":"2024-12-22T21:49:41","modified_gmt":"2024-12-22T21:49:41","slug":"cll-ibru","status":"publish","type":"project","link":"https:\/\/www.inab.certh.gr\/el\/project\/cll-ibru\/","title":{"rendered":"CLL-IBRU"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">We intend to explore two major mechanisms that may underlie less than optimal responses to BcR inhibition by ibrutinib, namely: &#8220;bypass&#8221; activation from non-BcR immune pathways, in particular the TLRs, resistance to signaling inhibitor-induced apoptosis in a context of BcR anergy associated with decreased dependence on proximal BcR signaling.<\/span><\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"class_list":["post-2318","project","type-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project\/2318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/types\/project"}],"wp:attachment":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/media?parent=2318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}