{"id":2311,"date":"2024-12-22T21:45:15","date_gmt":"2024-12-22T21:45:15","guid":{"rendered":"https:\/\/www.inab.certh.gr\/project\/p63\/"},"modified":"2024-12-22T21:45:15","modified_gmt":"2024-12-22T21:45:15","slug":"p63","status":"publish","type":"project","link":"https:\/\/www.inab.certh.gr\/el\/project\/p63\/","title":{"rendered":"P63"},"content":{"rendered":"<p><b>\u00a0<\/b><span style=\"font-weight: 400;\">The main objective of this Research Program is to define and understand the links between p63, immune signaling, and NF-\u03baB deregulation in CLL. Special focus will be given on the impact of p63 on CLL evolution, including resistance to and\/or progression after treatment with both chemoimmunotherapy and signaling inhibitors; as well as Richter\u2019s transformation. It aims at dissecting clinical aggressiveness in CLL and also in identifying optimal combinations of signaling inhibitors for a subgroup of patients with adverse prognosis, thus refining patient management.<\/span><\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"class_list":["post-2311","project","type-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project\/2311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/types\/project"}],"wp:attachment":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/media?parent=2311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}