{"id":2096,"date":"2024-12-22T21:21:42","date_gmt":"2024-12-22T21:21:42","guid":{"rendered":"https:\/\/www.inab.certh.gr\/project\/atxn1-med15-ppi\/"},"modified":"2024-12-22T21:22:56","modified_gmt":"2024-12-22T21:22:56","slug":"atxn1-med15-ppi","status":"publish","type":"project","link":"https:\/\/www.inab.certh.gr\/el\/project\/atxn1-med15-ppi\/","title":{"rendered":"ATXN1-MED15 PPI"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">\u03a0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u0391\u03a4\u03a7\u039d1-MED15 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 polyQ \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0397 \u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03bf-\u03c0\u03b1\u03c1\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03b4\u03b9\u03ba\u03ae \u03b1\u03c4\u03b1\u03be\u03af\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 1 (SCA1) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b8\u03b1\u03bd\u03b1\u03c4\u03b7\u03c6\u03cc\u03c1\u03b1 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b5\u03ba\u03c6\u03c5\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd polyQ. \u03a0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b5\u03c2 \u03c4\u03c1\u03b9\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd CAG \u03c3\u03c4\u03b7\u03bd \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03c3\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 ataxin-1 (\u0391\u03a4\u03a7\u039d1) \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b7 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03bd\u03b1 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03b3\u03bb\u03bf\u03c5\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2. \u0397 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03b1\u03bd\u03b1\u03b4\u03b9\u03c0\u03bb\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03c4\u03bf\u03be\u03b9\u03ba\u03ac \u03bf\u03bb\u03b9\u03b3\u03bf\u03bc\u03b5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03b5\u03bd\u03b4\u03bf\u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03bd\u03b5\u03c5\u03c1\u03bf\u03b5\u03ba\u03c6\u03cd\u03bb\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03af\u03b4\u03b1\u03c2. \u03a3\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b4\u03b5\u03af\u03be\u03b1\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7\u03c2 \u0391\u03a4\u03a7\u039d1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 MED15 (\u0391\u03a4\u03a7\u039d1-\u039c\u0395D15 PPI) \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ce\u03bd polyQ \u03c3\u03c5\u03c3\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u03a3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2, \u03b7 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0391\u03a4\u03a7\u039d1-\u039c\u0395D15 PPI \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03ad\u03c8\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf. \u03a3\u03ba\u03bf\u03c0\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03ad\u03c1\u03b3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03b9\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd ATNX1-MED15 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03bf\u03c5\u03c3\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b4\u03bf\u03bc\u03ae \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae polyQ \u03c3\u03c5\u03c3\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"class_list":["post-2096","project","type-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project\/2096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/types\/project"}],"wp:attachment":[{"href":"https:\/\/www.inab.certh.gr\/el\/wp-json\/wp\/v2\/media?parent=2096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}